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KMID : 0604520060320040263
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 4 p.263 ~ p.267
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Antioxidative and Anti-inflammatory Effects of Petasites japonicus
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Kim Jin-Hwa
Na Young
Sim Gwan-Sub
Lee Beom-Cheon
Pyo Hyeong-Bae
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Abstract
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Antioxidative and anti-inflammatory activities of Petasites japonicus extract were evaluated. P. japonicus extract showed 70.1% inhibition on peroxidation of linoleic acid. In the experiment using the cell permeable dye, 2’’,7’’- dichlorofluorescein diacetate (DCFDA) as an indicator of reactive oxygen species (ROS) generation, intracellular oxidative stress in UVB-irradiated keratinocytes was shown to be decreased by P. japonicus extract. Also, UVB-induced production of interleukin-1{alpha} and prostaglandin E_2 in human HaCaT keratinocytes was reduced in a dose-dependent manner by treatment with P. japonicus extract. All these results suggest that P. japonicus extract can be effectively used for prevention of UV-induced adverse skin reactions such as radical production and inflammation.
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KEYWORD
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Petasites japonicus, antioxidation, inflammation, keratinocytes, cytokine
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